Seminár z kvalitatívnej teórie diferenciálnych rovníc - Christopher Morison (6.11.2025)

vo štvrtok 16.11.2025 o 14:00 hod. v miestnosti M 223

29. 10. 2025 14.22 hod.
Od: Pavol Quittner

Prednášajúci: Christopher Morison

Názov prednášky: Somatic mutations accumulate stochastically in cancer cell populations

Termín: 6.11.2025, 14:00 hod., M 223

Abstrakt:
New distributions of mutational information are measurable thanks to single-cell sequencing technology. I first describe how some of these can be derived from a simple branching process model of neutral evolution. Using the neutral model as a baseline against which one can measure selection, I next consider cancer cells acquiring deleterious antigenic mutations, triggering the immune system, which seeks to eliminate them. Informed by stochastic simulations, I finally discuss what coevolutionary dynamics take place under different regimes of interactions between the immune cells and their cancer prey and how this can inform immunotherapeutic treatments.